Contrave and Marijuana Drug Interactions: Risks & Safety

Contrave is a prescription weight loss medication that combines bupropion and naltrexone to help compatible individuals manage obesity. However, patients using Contrave may also use marijuana, either recreationally or medicinally, raising concerns about possible drug interactions. The combined effects of these substances on the brain and body could pose significant health risks.

Understanding Contrave and marijuana drug interactions is critical for those considering if Contrave is the right fit for their weight loss journey.

Key Takeaways

• Drug Interactions: The combination of Contrave and marijuana may increase the risk of seizures, impact blood pressure, and alter the effects of other medications.
• Potential Health Risks: Taking Contrave while using marijuana could lead to serious side effects, including changes in mental health, increased heart rate, and impaired cognitive function.
• Medical Guidance: Patients should consult a doctor or pharmacist before using Contrave alongside marijuana to avoid adverse effects and ensure safety.

Understanding Contrave and Its Effects

Contrave is prescribed as an aid for weight loss in certain individuals with obesity or weight-related health conditions.

It contains two active ingredients:

• Bupropion: An antidepressant that can also help with smoking cessation and weight management. However, it carries a risk of seizures and has a boxed warning alerting doctors about potential suicidal thoughts.
• Naltrexone: An opioid antagonist used in treating opioid dependence and alcohol dependence. It blocks opioid receptors, helping to reduce food cravings but also impacting pain relief for those on opioid medications.

But what does Contrave do, especially when used with marijuana? The combination of these substances requires careful medical supervision due to the increased risk of side effects, particularly for individuals with preexisting health conditions such as high blood pressure, seizure disorder, or mental health conditions like bipolar disorder.

Contrave and Marijuana Drug Interactions: Risks & Recommendations

Category	Impact	Recommendation
Seizure Risk	Both Contrave and marijuana can lower the seizure threshold, increasing the risk of seizures.	Avoid combining these substances if prone to seizures; consult a healthcare provider.
Blood Pressure Fluctuations	Marijuana can cause fluctuations in blood pressure, while Contrave can increase it, leading to cardiovascular risks.	Monitor blood pressure closely; avoid marijuana if taking blood pressure medications.
Mental Health Changes	Combination may heighten suicidal thoughts, panic attacks, and mood swings, especially in individuals with bipolar disorder.	Seek medical advice before use, particularly if prone to anxiety, depression, or mood disorders.
Liver Damage	Both substances are metabolized in the liver, increasing the risk of liver damage over time.	Individuals with liver conditions should avoid combining these substances; routine liver tests recommended.
Impaired Cognitive Function	Neurotransmitter effects may impair judgment, coordination, and reaction time.	Avoid driving or operating heavy machinery when using either substance.
Increased Blood Pressure	Both substances may contribute to dizziness, headaches, and cardiovascular complications.	Monitor cardiovascular health and limit other stimulants like caffeine and nicotine.
Impaired Drug Effects	Marijuana can interfere with how other medications, including beta blockers, function in the body.	Consult a doctor or pharmacist before combining these substances.
Gastrointestinal Issues	Marijuana and Contrave can both affect digestion, causing nausea, vomiting, or irregular absorption of extended-release tablets.	If digestive discomfort occurs, assess whether marijuana may be contributing to the issue.

Marijuana’s Impact on the Body and Drug Interactions

Marijuana contains compounds like THC and CBD, which interact with the brain’s endocannabinoid system. While some individuals use marijuana to treat depression or anxiety, its effects on cognition, heart rate, and blood pressure can create complications when combined with other medications.

Potential Drug Interactions

Using marijuana alongside Contrave could lead to certain drug interactions that may increase the risk of adverse effects. Both substances impact the brain, cardiovascular system, and liver, and their combined effects may heighten risks for some individuals. Contrave contains bupropion, which influences dopamine and norepinephrine levels, and naltrexone, which blocks opioid receptors. Marijuana affects the endocannabinoid system, which plays a role in mood, cognition, and cardiovascular function.

The interaction between these substances can lead to unpredictable side effects, requiring careful consideration before using them together.

Seizure Risk

Both bupropion in Contrave and THC in marijuana can lower the seizure threshold, making seizures more likely, particularly in individuals with a history of seizure disorder or withdrawal symptoms from alcohol or opioids. The risk of seizures is especially concerning for individuals taking higher doses of Contrave or using marijuana frequently.

Patients with epilepsy or those prone to seizures should avoid this combination unless specifically advised by a healthcare provider.

Blood Pressure Fluctuations

Contrave is known to increase blood pressure, which can be dangerous for individuals with high blood pressure or severely high blood pressure. Marijuana can also cause fluctuations in blood pressure, leading to sudden spikes or drops that may result in dizziness, fainting, or an increased risk of side effects.

If a person is taking blood pressure medications or has a history of heart disease, mixing Contrave with marijuana could worsen cardiovascular risks. Regular blood pressure monitoring is recommended for anyone using this combination.

Mental Health Changes

Both Contrave and marijuana influence brain chemistry, and their combination can lead to panic attacks, mood swings, heightened suicidal thoughts, or worsened symptoms of bipolar disorder. While some individuals use marijuana to treat depression, its effects vary depending on the strain, dosage, and individual brain chemistry.

Marijuana’s impact on mental health conditions can be unpredictable, and when paired with Contrave, it may increase the risk of severe psychiatric symptoms. Individuals with a history of mental health changes or tricyclic antidepressant use should exercise caution when using these substances together.

Liver Damage

Both Contrave and marijuana are metabolized in the liver, meaning prolonged use of both substances could lead to liver damage or increased risk of adverse liver-related side effects. The liver is responsible for breaking down other medications, and the interaction between Contrave and marijuana may slow down or accelerate the metabolism of certain medications. This can lead to higher-than-intended drug concentrations in the bloodstream, increasing toxicity risks.

Patients with preexisting liver conditions or those taking other drugs that affect liver function should avoid combining these substances.

Impaired Cognitive Function

Since Contrave and marijuana both affect neurotransmitters, using them together may increase the risk of impaired cognitive abilities. This includes difficulties with judgment, problem-solving, reaction time, and motor skills.

Individuals who drive, operate heavy machinery, or perform tasks requiring focus should avoid using these substances together, as they may experience slowed reflexes, memory issues, and poor decision-making. The risk of side effects such as confusion or drowsiness increases with higher doses of marijuana or Contrave.

Risks and Side Effects of Mixing Contrave and Marijuana

The risk of Contrave side effects significantly increases when Contrave and marijuana are taken together, particularly in individuals with health conditions that make them more susceptible to adverse drug interactions. These side effects can range from mild discomfort to severe health complications requiring medical attention.

Understanding the potential risks can help individuals make informed decisions about their medication use.

Increased Blood Pressure

Since both substances can increase blood pressure, individuals may experience symptoms such as dizziness, headaches, heart palpitations, and shortness of breath. This can be especially concerning for those with severely high blood pressure or a history of cardiovascular disease.

If left unchecked, this combination may lead to an increased risk of heart attack or stroke in susceptible individuals. Monitoring blood pressure regularly and avoiding additional stimulants like caffeine or nicotine can help minimize the risks.

Mental Health Changes

Contrave has been associated with suicidal thoughts, and marijuana use may intensify symptoms of depression, anxiety, or paranoia. Individuals with a history of bipolar disorder or those taking other antidepressants may experience increased mood instability when combining these substances.

Since Contrave affects dopamine and norepinephrine levels, and marijuana influences serotonin and cannabinoid receptors, the interaction between the two could worsen preexisting mental health conditions.

Those with a history of mental health changes should speak to a doctor before using marijuana while on Contrave.

Impaired Drug Effects

Marijuana can interfere with the effectiveness of other medications, including certain beta blockers, making it challenging to manage blood pressure, heart rate, or anxiety symptoms. Additionally, the way Contrave interacts with marijuana may alter its weight loss effects, making it less effective at reducing cravings or appetite.

Individuals on weight loss drugs should be mindful that marijuana use could counteract their treatment goals. A doctor or pharmacist should be consulted to determine whether adjustments need to be made to medication dosages.

Gastrointestinal Issues

Both Contrave and marijuana can affect the digestive system, and their combination may increase the risk of nausea, vomiting, or stomach discomfort. Extended-release tablets of Contrave are designed to be absorbed gradually, but when taken with marijuana—particularly edible cannabis—digestive processes may slow down, potentially leading to inconsistent absorption.

This could result in unpredictable drug levels, causing fluctuations in appetite, metabolism, and overall effectiveness of the medication. Individuals who experience frequent gastrointestinal issues while using Contrave should consider whether marijuana may be contributing to their discomfort.

By understanding these risks and side effects, individuals can make safer choices regarding their use of Contrave and marijuana. Consulting a healthcare provider before combining these substances is highly recommended to ensure Contrave treatment remains effective and does not increase the risk of severe complications.

Who Is at the Highest Risk?

Certain individuals may be more vulnerable to Contrave drug interactions with marijuana, including those who:

• Have a seizure disorder or a history of opioid withdrawal symptoms
• Are prescribed weight loss drugs or other medications that affect serotonin or dopamine levels
• Have eating disorders, as both Contrave and marijuana can impact appetite regulation
• Suddenly stop drinking alcohol, as Contrave already carries risks for individuals with a history of alcohol dependence
• Are taking tricyclic antidepressants, which could interact with both substances

The Role of Medical Supervision

Before starting Contrave treatment, individuals should discuss their medical history and lifestyle habits, including marijuana use, with their healthcare provider.

A doctor or pharmacist can help determine whether the combination is safe and whether adjustments need to be made to existing treatments.

What to Discuss With Your Doctor:

• Any preexisting health history, including mental health conditions
• Use of related drugs, over-the-counter medications, or certain medications that might interact with Contrave
• The possibility of alternative weight loss drugs if Contrave poses risks

Healthcare providers may also recommend additional lab tests to monitor liver function and detect potential drug interactions.

Special Considerations for Women

Women taking Contrave should be especially cautious if they are pregnant, nursing, or planning to become pregnant. The drug can pass into breast milk and potentially affect an infant’s health.

Additionally, marijuana use during pregnancy is not recommended due to its impact on fetal brain development.

Emergency Situations and Adverse Reactions

In rare cases, a medical emergency may arise from severe interactions between Contrave and marijuana.

Symptoms requiring immediate attention include:

• Severe nausea, vomiting, or signs of liver damage
• Chest pain or dangerously high blood pressure
• Extreme confusion or mental health changes
• Difficulty breathing or an allergic reaction

If a person experiences a severe reaction, they should contact their local emergency number or seek help from a poison control center.

FAQ: Contrave and Marijuana Drug Interactions

When taking Contrave, understanding potential drug interactions is essential to ensure safety and effectiveness. Marijuana, whether used recreationally or medicinally, can affect how medications work in the body, raising concerns about its compatibility with Contrave and other prescription drugs.

This FAQ section addresses common questions about Contrave, its interactions with marijuana, and other important considerations. If you are currently taking Contrave or planning to use it alongside other substances, consulting a healthcare provider is always recommended.

1. What medications should not be taken with Contrave?

Certain medications can interact with Contrave, leading to increased risks of side effects or reduced effectiveness. Contrave should not be taken with opioid-containing medications, as it contains naltrexone, an opioid antagonist that can cause withdrawal symptoms in individuals with opioid dependence. Additionally, Contrave should not be taken with certain antihistamines, like Benadry, as Contrave and Benadryl drug interactions can occur.

Additionally, drugs that lower the seizure threshold, such as certain antidepressants, antipsychotics, or stimulants, may increase the risk of seizures when combined with Contrave. Blood pressure medications, certain beta blockers, and other drugs affecting dopamine and norepinephrine levels should also be used with caution.

Always consult a doctor or pharmacist before combining Contrave with other medications.

2. Does marijuana interact with any medication?

Marijuana can interact with various medications, potentially altering their effectiveness or increasing the risk of adverse effects. THC and CBD, the primary compounds in marijuana, affect liver enzymes responsible for drug metabolism, which can slow down or speed up how certain medications are processed.

Marijuana can enhance the sedative effects of central nervous system depressants, such as benzodiazepines and opioids, increasing the risk of drowsiness, dizziness, or respiratory depression. It may also interact with blood thinners, antidepressants, and medications that affect heart rate and blood pressure.

If you are taking prescription drugs, it is essential to discuss marijuana use with a healthcare provider to avoid unwanted interactions.

3. Does marijuana interact with Ozempic?

There is limited research on direct interactions between marijuana and Ozempic, a medication used for managing Type 2 diabetes and weight loss. However, marijuana can affect blood sugar levels, which could interfere with Ozempic’s effectiveness in regulating glucose.

Some users experience increased appetite from THC, potentially counteracting Ozempic’s appetite-suppressing effects, while CBD may contribute to lowering blood sugar. Additionally, because both substances can cause nausea in some individuals, using them together might increase the likelihood of gastrointestinal discomfort.

Patients using Ozempic should monitor their blood sugar levels closely and consult their doctor before using marijuana.

4. Does Contrave work for smoking?

Contrave is not specifically approved for smoking cessation, but it contains bupropion, an active ingredient in the smoking cessation drug Zyban. Bupropion helps reduce nicotine cravings and withdrawal symptoms, which may make quitting smoking easier for some individuals. However, Contrave also includes naltrexone, which is primarily used for weight management and opioid or alcohol dependence rather than smoking cessation.

While some patients may experience reduced cravings for cigarettes while on Contrave, it is not a first-line treatment for quitting smoking. If smoking cessation is a goal, a doctor may recommend Zyban or other proven smoking cessation therapies.

5. What to avoid while on Contrave?

Certain substances and behaviors should be avoided while taking Contrave to minimize risks and maximize effectiveness. Drinking alcohol, particularly in large amounts, should be avoided because it may increase the likelihood of seizures and worsen side effects like dizziness or nausea. High-fat foods should also be limited, as they can increase the absorption of Contrave, potentially leading to higher blood levels and increased side effects.

Patients should be cautious with other medications, including opioids, as naltrexone in Contrave can block their effects and cause withdrawal. Additionally, using marijuana or other central nervous system depressants may heighten drowsiness, mood changes, or cardiovascular risks.

Consulting a healthcare provider before adding or stopping any medication is essential while taking Contrave.

Conclusion

Combining Contrave with marijuana presents potential risks due to certain drug interactions affecting blood pressure, seizure risk, and mental health. Those taking Contrave should consult a doctor or pharmacist before using marijuana to avoid complications. Following professional medical advice is essential to increase the chances of successful weight management while minimizing adverse effects.