Contrave and Mounjaro Together: Potential Drug Interactions

The use of Contrave and Mounjaro together for weight loss has sparked interest among individuals seeking effective treatment options. As two FDA-approved weight loss medications, Contrave and Mounjaro work through different mechanisms, raising questions about their potential synergy and possible drug interactions.

While some patients may see promising weight loss benefits with these two medications, there are critical safety considerations to address.

This article explores how taking Contrave and taking Mounjaro may affect the body, their combined impact on body mass index and weight loss, and the precautions necessary for safe use.

Key Takeaways

• Contrave and Mounjaro work differently for weight loss. While Contrave suppresses appetite and reduces food cravings, Mounjaro affects gut hormones to improve insulin sensitivity and regulate blood sugar levels.
• Combining these medications may increase the risk of side effects. Patients taking Mounjaro and Contrave together should be aware of potential interactions, including changes in blood pressure, mood, and digestive issues.
• Consulting a healthcare provider is essential. Anyone considering Contrave and Mounjaro together should discuss their weight loss goals, family history, and other medications with their doctor before starting a treatment plan.

Understanding Contrave and Mounjaro

Contrave is a prescription weight loss medication, a combination medication of two active ingredients: bupropion, an antidepressant and smoking cessation aid, and naltrexone, an opioid antagonist. This combination helps suppress appetite and reduce food cravings, helping compatible individuals lose weight.

Contrave is approved by the FDA for chronic weight management in adults who have a BMI of 30 or higher, or a BMI of 27 accompanied by at least one weight-related medical condition.

Mounjaro is an injectable medication that belongs to the GLP-1 and GIP receptor agonist families. Originally approved for type 2 diabetes, its weight-loss benefits have made it a popular option for those with weight-related health conditions seeking long-term weight reduction.

This once-weekly injection regulates blood sugar levels, enhances insulin sensitivity, and slows digestion, reducing calorie intake.

Contrave and Mounjaro – Comparison and Potential Interactions

Category	Contrave	Mounjaro
Mechanism of Action	Suppresses appetite, reduces cravings	Regulates blood sugar, slows digestion, reduces hunger
Active Ingredients	Bupropion (antidepressant), Naltrexone (opioid antagonist)	Tirzepatide (GLP-1 and GIP receptor agonist)
FDA Approval	Chronic weight management (BMI ≥30, or BMI ≥27 with comorbidities)	Originally for type 2 diabetes, now used for weight loss
Dosing	Oral tablets, taken daily	Weekly injection (arm, thigh, or abdomen)
Primary Weight Loss Effects	Reduces emotional eating and cravings	Enhances insulin sensitivity, delays gastric emptying
Common Side Effects	Nausea, constipation, dry mouth, increased blood pressure, mood changes	Nausea, bloating, delayed digestion, low blood sugar
Potential Drug Interactions	Interacts with opioids, MAO inhibitors, and stimulants	May amplify effects of insulin, diabetes medications
Impact on Blood Sugar	Indirectly affects metabolism and calorie intake	Lowers blood sugar, improves insulin sensitivity
Impact on Blood Pressure	May increase blood pressure	May lower blood pressure
Mood Effects	May cause mood changes, anxiety, or suicidal thoughts	No direct effect, but metabolic changes may impact mood
Ideal for Individuals Who…	Struggle with emotional eating or compulsive snacking	Need improved insulin function and appetite regulation
Monitoring Considerations	Blood pressure, mood changes, drug interactions	Blood sugar levels, digestive changes, fatigue
Best Used With…	Calorie-restricted diet, exercise	Balanced diet, regular exercise

How Contrave and Mounjaro Affect Weight Loss

Both Contrave and Mounjaro are FDA-approved weight loss medications, but they function through distinct mechanisms in the body. Understanding how each medication works can help patients determine which option—or combination—is best suited for their needs.

Contrave: Targeting the Brain’s Reward System

How does Contrave work for weight loss? Contrave is an oral weight loss medication that combines two active ingredients:

• Bupropion, an antidepressant that influences dopamine and norepinephrine levels, helping regulate appetite and mood.
• Naltrexone, an opioid antagonist that alters the brain’s reward response to food, making eating less pleasurable.

These ingredients work together to help individuals suppress appetite, reduce food cravings, and minimize emotional eating. This can be particularly beneficial for people who struggle with stress eating or compulsive snacking.

Contrave is most effective for weight loss when combined with a calorie-restricted diet and regular exercise, as its primary role is to help certain patients stick to their diet by curbing the urge to overeat.

Mounjaro: Enhancing Insulin Sensitivity and Hunger Control

Mounjaro is an injectable medication from the agonist family of GLP-1 and GIP receptor agonists. Mounjaro acts by imitating gut hormones, effectively reducing appetite and cravings by targeting the brain’s appetite control center. Essentially, it mimics the effects of gut hormones that play a role in:

• Regulating blood sugar – Improves insulin sensitivity, which helps the body use glucose more effectively.
• Delaying gastric emptying – Slows digestion, keeping individuals feeling fuller for longer and reducing calorie intake.
• Suppressing appetite – Affects brain receptors that control hunger and satiety.

Originally developed for type 2 diabetes, Mounjaro has shown considerable weight loss benefits in both diabetic and non-diabetic participants struggling with obesity. The medication is typically administered as a once-weekly injection in the upper arm, thigh, or abdomen.

Comparing Weight Loss Effects: Contrave vs. Mounjaro

Clinical studies indicate that taking Mounjaro can lead to a higher percentage of average weight loss compared to Contrave. Mounjaro’s impact on gut hormones and insulin sensitivity often results in more significant weight reduction, particularly for certain individuals with metabolic conditions such as high blood pressure, high cholesterol, or insulin resistance.

However, Contrave remains a valuable option for patients whose primary challenge is resisting food cravings. It is especially effective in people who eat in response to emotions rather than true hunger.

A treatment group experienced notable weight loss effects when using Mounjaro, particularly when combined with a calorie-restricted diet and regular exercise. Meanwhile, Contrave demonstrated effectiveness in aiding non-diabetic participants who struggled with emotional and habitual eating patterns.

Ultimately, both medications have their place in weight loss treatment. The best option depends on individual weight loss goals, eating behaviors, and underlying health conditions.

Potential Drug Interactions Between Contrave and Mounjaro

While both Contrave and Mounjaro are effective weight loss medications, combining them may lead to unexpected effects. Each drug influences the body differently, and using them together could amplify or counteract certain responses.

Before taking Contrave and Mounjaro together, patients should understand the potential risks and consult a healthcare provider to ensure safe use.

1. Changes in Blood Sugar Levels

One of the primary concerns when combining these medications is the impact on blood sugar levels.

• Mounjaro lowers blood sugar by improving insulin sensitivity and slowing digestion. This is particularly beneficial for individuals with type 2 diabetes or non-diabetic participants struggling with insulin resistance. However, in some cases, the medication can lead to low blood sugar, causing dizziness, fatigue, or shakiness.
• Contrave’s effect on metabolism can interfere with glucose regulation. While it does not directly alter insulin function like Mounjaro, it can affect energy balance and calorie intake, which may lead to unpredictable shifts in blood sugar levels.

For patients using both medications, frequent blood glucose monitoring is essential to prevent hypoglycemia or excessive dips in energy levels. The same drug interaction effects can occur by taking Contrave and Metformin together.

2. Blood Pressure Fluctuations

Blood pressure regulation is another key concern when using Contrave and Mounjaro together.

• Contrave may raise blood pressure, particularly in the early stages of treatment. This is due to its active ingredients, which stimulate the central nervous system and increase heart rate. For patients with high blood pressure or high cholesterol, this could pose a significant risk.
• Mounjaro, on the other hand, may lower blood pressure by improving metabolic function and reducing insulin sensitivity. While this can be beneficial for cardiovascular health, combining it with Contrave may create an unpredictable balance—potentially causing sudden spikes or drops in blood pressure.

Patients with a history of high blood pressure should work closely with their healthcare provider to monitor their cardiovascular health and adjust dosages as needed.

3. Mood Changes and Suicidal Thoughts

One of the lesser-known but serious risks associated with taking Contrave is its potential impact on mood.

• Bupropion, a key ingredient in Contrave, is an antidepressant, meaning it alters brain chemistry to influence dopamine and norepinephrine levels. While this can help with food cravings and emotional eating, it can also contribute to mood changes, anxiety, or agitation in some individuals.
• Some patients have reported increased suicidal thoughts while using Contrave. This risk is particularly high for individuals with a history of depression or mental health conditions.

While Mounjaro is not directly linked to mood-related side effects, its influence on metabolic function and energy expenditure may indirectly impact emotional well-being.

Patients experiencing mood swings, depression, or thoughts of self-harm should discontinue use and seek medical attention immediately.

Doctor’s Perspective on Drug Interactions

Dr. Matthew Olesiak, MD, Chief Medical Director of SANE MD, stresses the importance of medical supervision when considering this combination:

“While Contrave and Mounjaro offer unique weight loss benefits, combining them without medical supervision can lead to unpredictable effects, especially for individuals managing high blood pressure or other medications that affect metabolism.”

Given the complexity of these medications, patients should never adjust dosages or combine treatments without first consulting their doctor.

Regular check-ups, blood pressure monitoring, and tracking any mood-related symptoms are essential steps in ensuring safe use.

Who Should Consider This Combination?

Patients with high cholesterol, high blood pressure, or a family history of metabolic disorders should be cautious when considering Contrave and Mounjaro together.

A healthcare provider may recommend:

• Starting with a low dose of one medication before introducing the second.
• Monitoring blood pressure and blood sugar levels regularly.
• Following a balanced diet and regular exercise plan to maximize results.

Side Effects to Watch For

Both Contrave and Mounjaro are effective weight loss medications, but they come with potential side effects.

When combined, these risks may be amplified, making it essential for patients to monitor their response and consult a healthcare provider if any issues arise.

1. Digestive Issues

Gastrointestinal side effects are among the most commonly reported issues with both medications.

• Contrave can cause nausea, vomiting, constipation, and dry mouth. This is due to its impact on the central nervous system and digestive processes. The medication influences appetite regulation in the brain, but it can also slow bowel movements and decrease saliva production, leading to discomfort. Check out our guide to Contrave drug interactions for more symptoms.
• Mounjaro delays gastric emptying, which may lead to nausea, bloating, and in some cases, diarrhea. While this mechanism helps reduce calorie intake, it can also cause prolonged feelings of fullness, making it difficult for some individuals to eat regular meals.

When used together, these medications may intensify digestive discomfort, leading to prolonged nausea or constipation.

Patients should ensure they stay hydrated and consume a fiber-rich balanced diet to support digestion.

2. Blood Sugar Fluctuations

Because taking Mounjaro directly affects blood sugar levels by improving insulin sensitivity, it can increase the risk of low blood sugar (hypoglycemia), particularly when combined with other medications that impact metabolism.

• Mounjaro slows glucose absorption, which can lead to dizziness, fatigue, and lightheadedness if blood sugar drops too low.
• Contrave, while not a diabetes medication, affects the body’s energy balance and may indirectly interfere with glucose regulation.

For patients without diabetes, this interaction may not be as pronounced.

However, those with metabolic conditions or a history of unstable blood glucose should monitor for signs of low blood sugar, including headaches, shakiness, and irritability.

3. Blood Pressure Changes

Both medications have opposing effects on blood pressure, making it crucial for individuals with hypertension or cardiovascular concerns to exercise caution.

• Contrave may increase blood pressure, especially in the initial stages of use or at a higher dose. Its stimulant-like effect on the nervous system can raise heart rate, which may be problematic for those with a history of high blood pressure or high cholesterol.
• Mounjaro, on the other hand, can lower blood pressure due to its effect on metabolic health and insulin regulation.

When taking Contrave and Mounjaro together, some patients may experience fluctuations between high and low blood pressure, which can lead to dizziness, fatigue, or an increased risk of fainting.

Those with preexisting hypertension should monitor their readings closely and discuss any unusual symptoms with their doctor.

4. Fatigue and Insomnia

Changes in energy levels are common with both medications, but for different reasons.

• Contrave can cause restlessness and difficulty sleeping, particularly in the beginning stages. It contains bupropion, a mild stimulant that may increase wakefulness and disrupt sleep cycles, leading to insomnia.
• Mounjaro regulates energy expenditure and can sometimes cause fatigue, particularly if blood sugar levels fluctuate too much.

When combined, these effects may lead to increased daytime tiredness while also causing nighttime restlessness.

Establishing a consistent sleep routine, avoiding caffeine late in the day, and discussing medication timing with a healthcare provider may help minimize disruptions.

Doctor’s Perspective on Managing Side Effects

Dr. Olesiak emphasizes the importance of monitoring side effects and making early adjustments:

“Patients taking Contrave or taking Mounjaro should pay close attention to side effects and report any concerns to their healthcare provider. Adjusting the treatment plan early can prevent serious complications.”

Because every individual responds differently to anti-obesity medications, it’s crucial to stay aware of how the body reacts and address any concerns promptly.

If side effects become severe or persistent, a healthcare provider may recommend a low dose adjustment or an alternative weight loss treatment.

Frequently Asked Questions (FAQ)

Many people who consider Contrave and Mounjaro together or as part of a broader weight loss treatment have concerns about medication interactions, safety, and how to maximize weight loss benefits.

Below are answers to common questions to help clarify potential risks and best practices when using these weight loss medications.

1. What medications should not be taken with Contrave?

Several other medications, including opioids, may interact with taking Contrave. For example, combining Contrave and fentanyl should be avoided due to potentially severe drug interactions. This is because Contrave contains naltrexone, which blocks opioid receptors and can cause sudden withdrawal symptoms in individuals using painkillers.

Additionally, other antidepressants, especially MAO inhibitors (such as phenelzine or selegiline), can increase the risk of dangerous side effects, including high blood pressure and serotonin syndrome. Stimulants, seizure medications, and drugs affecting blood pressure should also be used with caution.

Always consult a healthcare provider before starting Contrave if you are on other treatments.

2. Can you take Contrave and semaglutide at the same time?

Semaglutide, the active ingredient in Wegovy and Ozempic, is another GLP-1 receptor agonist similar to taking Mounjaro. In theory, Contrave and semaglutide could be used together, but combining them may increase the likelihood of nausea, gastrointestinal side effects, and blood sugar fluctuations.

Additionally, Contrave has a stimulant effect, while semaglutide works by slowing digestion—together, this could create unpredictable metabolic responses.

A healthcare provider can help determine whether combining these weight loss medications is safe for your specific needs and weight loss goals.

3. Can I take bupropion with Mounjaro?

Bupropion, a component of Contrave, is sometimes prescribed separately as an antidepressant or smoking cessation aid. While there is no direct contraindication for taking bupropion with Mounjaro, caution is advised. Bupropion can increase heart rate and raise blood pressure, while Mounjaro may lower it, leading to unpredictable cardiovascular effects.

Additionally, since bupropion influences dopamine and norepinephrine levels, patients should monitor for mood changes or increased anxiety.

Always discuss the potential risks and benefits with a healthcare provider before combining these medications.

4. How to speed up weight loss on Mounjaro?

To enhance Mounjaro’s weight-loss effects, patients should focus on maintaining a calorie-restricted diet, incorporating regular exercise, and prioritizing lifestyle changes. Eating a balanced diet rich in protein, fiber, and healthy fats can support satiety, while minimizing processed foods and excessive sugars will help regulate blood sugar levels. Strength training and cardiovascular exercise can further improve energy expenditure and metabolic function.

Additionally, staying consistent with the once-weekly injection schedule and monitoring progress with a healthcare provider can optimize results.

5. What medications should not be taken with Contrave?

In addition to opioid painkillers and MAO inhibitors, taking Contrave should be avoided alongside medications that lower seizure thresholds, such as tramadol or antipsychotic drugs. Combining Contrave with other stimulant-like medications, including amphetamines or certain ADHD treatments, may lead to increased blood pressure and heart rate, which could be dangerous.

Since Contrave also affects mood and appetite regulation, individuals taking antidepressants, mood stabilizers, or other psychiatric medications should consult their doctor to ensure safe use.

Always review your full medication list with a healthcare provider before starting Contrave.

This FAQ section provides essential information for anyone considering Contrave and Mounjaro together or looking for ways to optimize their weight loss journey. If you have additional concerns, speaking with a medical professional is the best way to ensure safe and effective treatment.

Final Thoughts on Combining Contrave and Mounjaro

While Contrave and Mounjaro together may provide enhanced weight loss effects, this combination is not suitable for everyone.

Patients should prioritize safety, understand Contrave interact risks, and work with a doctor to create a sustainable weight loss treatment plan.

A well-rounded treatment plan includes:

• A calorie-restricted diet and a healthy diet
• Regular exercise and lifestyle changes
• Careful monitoring of other medications and health conditions

Before starting any new medications, consult a healthcare provider to determine the safest and most effective approach for long-term chronic weight management.