Contrave Side Effects
Dr. Matthew Olesiak, MD, is the Chief Medical Director at SANESolution, a renowned wellness technology company dedicated to providing evidence-based solutions for optimal living. Dr. Olesiak earned his medical degree from the prestigious Jagiellonian University Medical College in Kraków, Poland, where he developed a strong foundation in medicine.
Contrave is a prescription medication used for weight loss and weight management in adults. It combines two medicines, naltrexone and bupropion (consider our article on Contrave and Depression if this may be you), which work together to help reduce hunger and increase feelings of fullness. While Contrave can be an effective tool for weight loss, it can also cause side effects, some of which can be serious. In this article, we will discuss the common Contrave side effects, how to manage them, and special precautions to take when using this medication.
Key Takeaways
- Effective Weight Management Aid: Contrave combines naltrexone and bupropion to help reduce cravings and support long-term weight loss when paired with diet and exercise.
- Mild to Serious Side Effects: Common side effects like nausea and headaches often subside over time, but serious risks, including suicidal thoughts, require close monitoring.
- Important Precautions: Avoid alcohol, high-fat meals, and certain medications while on Contrave, and consult your doctor regularly to ensure safe and effective use.
What Does Contrave Do for Weight Loss?
Contrave’s active ingredients, naltrexone and bupropion, work on the brain’s reward system and appetite regulation. This combination helps reduce food cravings and supports long-term weight management for compatible individuals.
In clinical trials, patients taking Contrave experienced significant reductions in body weight compared to those in the placebo group.
Common Side Effects of Contrave
Most individuals tolerate Contrave well, but it may cause common side effects, including:
- Nausea
- Dry mouth
- Trouble sleeping
- Headache
- Dizziness
- Constipation
These symptoms are typically mild and may subside as your body adjusts to the medication. However, if symptoms persist, consult your healthcare provider.
Table of Common Contrave Side Effects
| Side Effect | Description | Frequency/Notes |
|---|---|---|
| Nausea | Feeling queasy or an upset stomach | Common; may diminish after the first few weeks |
| Dry Mouth | Persistent dryness or thirst | Typically mild and manageable with hydration |
| Trouble Sleeping | Difficulty falling or staying asleep | Often temporary; improve sleep hygiene |
| Headache | Mild to moderate pain in the head | Can be managed with hydration and rest |
| Dizziness | Feeling lightheaded or unsteady | Sit or lie down if symptoms occur |
| Constipation | Difficulty with bowel movements | Increase fiber and fluid intake |
Serious Contrave Side Effects
While rare, some users may experience serious side effects requiring immediate medical attention. These include:
- High blood pressure
- Chest pain
- Trouble breathing
- Seizures
- Serious allergic reaction (e.g., rash, swelling, difficulty breathing)
- Suicidal thoughts or changes in behavior, particularly in young adults
If you notice any of these symptoms, contact your doctor immediately or call your local emergency number.
Managing Side Effects
Most side effects of Contrave are mild and temporary, but some can be serious. If you experience any side effects, it is essential to talk to your doctor.
Here are some tips for managing common side effects:
- Nausea: Take Contrave with a meal to reduce nausea. Avoid taking it with high-fat meals, as this can increase side effects.
- Constipation: Increase fiber intake and stay hydrated to help alleviate constipation.
- Headache: Manage headaches with hydration, a consistent sleep schedule, and regular exercise.
- Dizziness: Move slowly and sit down if you feel dizzy to prevent falling.
- Trouble sleeping: Practice good sleep hygiene, such as following a regular sleep schedule and creating a sleep-conducive environment.
Boxed Warning for Contrave
The Food and Drug Administration (FDA) has issued a boxed warning for Contrave due to the risk of suicidal thoughts and behaviors, particularly in individuals with a history of mental health conditions or bipolar disorder.
Regular monitoring by a healthcare provider is recommended for patients starting Contrave.
Special Precautions
Before taking Contrave, it is essential to discuss your medical history with your doctor.
Certain medical conditions, such as high blood pressure, heart problems, seizures, glaucoma, diabetes, liver or kidney problems, or a history of an allergic reaction to Contrave or its ingredients, may require special precautions or contraindicate the use of Contrave.
- High blood pressure: Contrave may increase blood pressure, so it is essential to monitor blood pressure regularly.
- Low blood sugar: Contrave may increase the risk of hypoglycemia (low blood sugar) in patients with diabetes.
- Allergic reactions: Contrave can cause serious allergic reactions, including anaphylaxis, which can be life-threatening.
- Suicidal thoughts: Contrave may increase the risk of suicidal thoughts and behaviors, especially in children and young adults.
- Mental health conditions: Contrave may not be suitable for people with certain mental health conditions, such as bipolar disorder or eating disorders.
Stopping or Missing Doses
If you need to stop taking Contrave, it is essential to talk to your doctor first. Stopping Contrave suddenly can cause withdrawal symptoms, although this is rare.
If you miss a dose, take it as soon as you remember, but do not take two doses at the same time.
Pregnancy and Breastfeeding
Contrave is not recommended during pregnancy or breastfeeding.
Weight loss during pregnancy may cause fetal harm, and Contrave can pass into breast milk and cause harm to a child.
Long-term Effects
The long-term effects of Contrave are not well understood. However, it is essential to monitor side effects and adjust the dosage or discontinue treatment if necessary. Regular monitoring of blood pressure, liver function, and kidney function is recommended.
In conclusion, while Contrave can be an effective tool for weight loss in certain individuals, it is essential to be aware of the potential side effects and take special precautions to manage them.
By discussing your medical history with your doctor and following the recommended dosage and monitoring schedule, you can minimize the risk of side effects and achieve successful weight loss.
Who Should Avoid Taking Contrave?
Contrave is not suitable for everyone. Avoid taking Contrave if you:
- Have uncontrolled high blood pressure
- Are pregnant or breastfeeding (due to potential fetal harm or transfer through breast milk)
- Have a history of seizure disorder
- Are currently taking monoamine oxidase inhibitors
- Have a history of opioid withdrawal or are using opioids
- Have angle-closure glaucoma
What to Avoid While on Contrave
To minimize side effects and enhance effectiveness, avoid:
- Drinking alcohol, as it may increase the risk of seizures and other adverse effects.
- High-fat meals, which can elevate blood levels of the medication and lead to nausea.
- Using other drugs or medications without consulting your healthcare provider.
How Long Do Contrave Side Effects Last?
The duration of side effects varies depending on the individual. Common symptoms such as nausea and dry mouth may subside within a few weeks as the body adjusts.
However, more severe side effects may require discontinuation of the medication and further evaluation by a healthcare provider.
Potential Drug Interactions
Contrave may interact with other medications, including:
- Antidepressants
- Blood pressure medications
- Seizure medications
- Opioids
Always keep your healthcare provider updated on your medical history and any medications you are currently using to prevent potential drug interactions.
Clinical Trials and Effectiveness
In clinical trials, patients using Contrave in conjunction with a reduced-calorie diet and exercise achieved significant weight loss compared to those in the placebo group.
These results highlight the importance of combining medication with lifestyle changes for optimal outcomes.
FAQs About Contrave Side Effects
When considering a weight loss treatment like Contrave, it’s natural to have questions about its safety, effectiveness, and potential side effects. Understanding how Contrave works and how to manage its possible downsides can help you make informed decisions about whether it’s the right choice for your weight management journey.
Below, we’ve compiled answers to some of the most frequently asked questions about the Contrave side effects to guide you further.
What Is the Downside of Contrave?
Contrave has several potential downsides, primarily related to its side effects. Some typical side effects may include feelings of nausea, constipation, dryness in the mouth, dizziness, and difficulties with sleep. For some individuals, these symptoms can be mild and resolve over time, while others may find them disruptive.
Additionally, Contrave carries a risk of more serious side effects, such as increased blood pressure or heart rate and, in rare cases, suicidal thoughts or behavior. Due to these risks, close monitoring by a healthcare provider is essential, particularly during the initial weeks of treatment.
How Long Do Contrave Side Effects Last?
The duration of Contrave side effects varies by individual. Common symptoms like nausea, headache, or dry mouth often diminish within the first few weeks as the body adjusts to the medication. However, more persistent or severe symptoms, such as significant mood changes or elevated blood pressure, may require medical intervention.
If side effects last longer than expected or interfere with daily life, consult your healthcare provider for personalized advice or adjustments to your treatment plan.
How Much Weight Do You Lose With Contrave?
Weight loss results with Contrave can vary significantly depending on factors like adherence to lifestyle changes and individual metabolism. In clinical studies, patients using Contrave in combination with a reduced-calorie diet and regular exercise experienced an average weight loss of 5-10% of their starting weight over 6 to 12 months. Some individuals may achieve greater reductions, especially when following a comprehensive weight management program.
It’s important to note that weight loss progress is gradual, and maintaining healthy habits is key to sustaining results.
What to Avoid While on Contrave?
Certain activities and substances should be avoided while taking Contrave to ensure safety and efficacy.
These include:
- Alcohol Consumption: Drinking alcohol can increase the risk of adverse side effects, such as dizziness or mood changes, and may interfere with weight loss efforts.
- High-Fat Meals: High-fat meals can increase the risk of nausea and other gastrointestinal symptoms when taken with Contrave.
- Certain Medications: Avoid taking other prescription or over-the-counter medications, particularly those that affect the central nervous system or appetite, without consulting your doctor.
- Operating Heavy Machinery: Until you know how Contrave affects you, avoid driving or using heavy machinery, as it can cause dizziness or impaired alertness.
Always discuss any concerns or lifestyle adjustments with your healthcare provider to optimize your treatment experience.
Conclusion
Contrave is a valuable tool for weight management in certain individuals with obesity or weight-related conditions. By understanding and managing the side effects of Contrave, patients can safely incorporate it into their weight loss program.
Always consult a healthcare provider for personalized advice and monitoring.
For additional information, visit the FDA’s page on Contrave (opens in a new tab) or explore resources from trusted organizations like Mayo Clinic
