Contrave is a prescription medication designed for weight management in a subset of adults struggling with obesity or a weight-related medical condition. Among its potential side effects, Contrave constipation is a common issue that some users experience. Indeed, there is an increased risk of side effects like constipation when taking Contrave, especially when combined with alcohol or high-fat meals.

This article explores the relationship between Contrave constipation, its causes, and strategies for managing this side effect.

Key Takeaways

• Common Side Effects and Precautions: Contrave is a weight management medication combining naltrexone and bupropion. Common side effects include constipation, nausea, and headaches, while serious risks include suicidal thoughts (boxed warning) and allergic reactions. Patients with certain medical conditions, such as eating disorders or a history of substance abuse, should avoid Contrave.
• Managing Constipation: Constipation caused by Contrave is often temporary and can be alleviated by increasing dietary fiber, staying hydrated, exercising, or using over-the-counter remedies like Miralax under medical supervision.
• Lifestyle Recommendations for Effectiveness: To maximize Contrave’s benefits, follow a reduced-calorie diet rich in fiber, engage in regular physical activity, avoid high-fat meals, and maintain good sleep hygiene. Always consult a healthcare provider for personalized guidance and to manage side effects.

What is Contrave and How Does it Work?

Contrave is a prescription medication used for weight loss and weight management in certain adults. It combines two active drugs: naltrexone and bupropion. Taken orally, Contrave must be swallowed whole. While the exact mechanism of action is not fully understood, it is believed to target areas of the brain, such as the hypothalamus and dopamine pathways. The hypothalamus is a gland that helps control appetite, while dopamine is a chemical responsible for pleasure and reward.

By potentially increasing dopamine levels and acting on the hypothalamus, Contrave may help decrease appetite in compatible individuals, aiding in weight loss efforts.

Does Naltrexone Make You Constipated?

One of the active ingredients in Contrave, naltrexone hydrochloride, can influence the digestive system by interacting with opioid receptors. While naltrexone is primarily an opioid antagonist designed to block the effects of opioids on these receptors, it may inadvertently impact normal gut motility. The gut’s opioid receptors play a role in regulating peristalsis, the wave-like contractions that move food through the digestive system. By altering this regulation, naltrexone can slow intestinal movement, leading to constipation in some individuals.

Additionally, when combined with bupropion hydrochloride, which has its own effects on neurotransmitters such as dopamine and norepinephrine, this interaction can further influence gut-brain signaling and exacerbate gastrointestinal symptoms. Together, these ingredients may reduce gut motility and fluid secretion, increasing the likelihood of constipation, especially in individuals already prone to digestive issues.

Additionally, naltrexone can cause a serious allergic reaction, and immediate medical attention is necessary if such reactions occur.

What Is the Most Common Side Effect of Contrave?

While side effects of Contrave vary among individuals, some of the most common include:

• Nausea
• Constipation
• Dry mouth
• Trouble sleeping
• Headaches
• Individuals with bipolar disorder should be cautious as the medication may trigger manic episodes

Boxed Warning: Risk of Suicidal Thoughts and Behaviors

Contrave carries a boxed warning due to the risk of suicidal thoughts and behaviors. Antidepressants like bupropion, one of the components of Contrave, can increase the risk of suicidal thoughts and behaviors in individuals with depression or certain mental health conditions. This risk is particularly noted in children, adolescents, and adults up to 24 years of age.

If you experience any changes in mood or suicidal thoughts while taking Contrave, it is crucial to report them to your healthcare provider immediately.

Precautions and Contraindications

Certain individuals should not take Contrave due to the potential for serious harm. Those with a history of suicidal thoughts or behaviors, substance abuse, or liver disease should avoid this medication. Additionally, Contrave should not be taken during pregnancy or breastfeeding, as it may cause fetal harm or pass into breast milk, potentially harming the child.

If you have any medical conditions such as high blood pressure, heart disease, or mental health conditions, inform your healthcare provider before starting Contrave. It is also essential to disclose all medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and supplements, as they may interact with Contrave.

Does Contrave Constipation Go Away?

For most patients, constipation associated with Contrave is a temporary issue as the body adjusts to the medication. If symptoms persist, consult your healthcare provider for guidance.

Can You Take Miralax with Contrave?

Yes, over-the-counter laxatives like Miralax may help alleviate constipation while taking Contrave.

However, always tell your healthcare provider before adding any new medication, including laxatives, to avoid potential drug interactions.

Foods to Avoid While Taking Contrave

Certain foods may exacerbate constipation or interfere with Contrave’s effectiveness. Avoid:

• High-fat meals: These can increase nausea and affect how the medication is absorbed.
• Processed foods low in fiber.

Instead, focus on a healthy diet rich in:

• Fiber (e.g., fruits, vegetables, legumes).
• Hydrating foods to maintain regular bowel movements.

Additionally, individuals with eating disorders such as anorexia nervosa or bulimia should not take Contrave due to potential health risks.

How to Relieve Constipation While Taking Contrave

If you experience constipation while taking Contrave, consider these strategies:

1. Increase fiber intake: Incorporate more fruits, vegetables, and legumes into your diet.
2. Stay hydrated: Drink plenty of water to help move food through your digestive system.
3. Physical activity: Regular exercise can promote healthy digestion.
4. Over-the-counter remedies: Options like Miralax or fiber supplements may help, but consult your healthcare provider first.

How to Relieve Constipation While Taking Contrave

Strategy	Details	Tips for Implementation
Increase Fiber Intake	Add more fruits, vegetables, and legumes to your diet.	Start with small portions of high-fiber foods to avoid bloating and gradually increase intake.
Stay Hydrated	Drinking plenty of water helps soften stool and maintain regular bowel movements.	Aim for 8–10 glasses of water daily; include hydrating foods like cucumber and watermelon.
Physical Activity	Exercise promotes healthy digestion and reduces constipation symptoms.	Include daily walks, yoga, or light cardio to support digestion and overall well-being.
Over-the-Counter Remedies	Products like Miralax or fiber supplements can provide short-term relief.	Always consult your healthcare provider before adding any laxatives or supplements.

Managing Other Side Effects of Contrave

In addition to constipation, Contrave may cause other side effects, such as:

• High blood pressure: Regularly monitor your blood pressure while on Contrave.
• Withdrawal symptoms: Discuss any history of opioid use with your doctor before starting Contrave.
• Suicidal thoughts: If you experience mood changes or mental health conditions worsen, contact your healthcare provider immediately.

There is an increased risk of side effects when Contrave is combined with alcohol or high-fat meals.

When to Seek Medical Attention

If you experience severe or persistent side effects, such as:

• Life-threatening allergic reactions (e.g., difficulty breathing, swelling).
• Severe constipation or abdominal pain.
• Worsening mood or suicidal thoughts.

Contact your healthcare provider or call your local emergency number immediately.

Clinical Studies on Contrave’s Side Effects

Clinical trials for Contrave have demonstrated its efficacy in supporting weight loss, but they also identified constipation as a common side effect.

These studies emphasize the importance of pairing Contrave with lifestyle changes, such as a healthy diet and exercise, to maximize results and minimize side effects.

Tips to Maximize Weight Loss on Contrave

While Contrave can be an effective tool for weight management, its success largely depends on how well it is integrated with healthy lifestyle habits. By adopting a holistic approach that includes mindful eating, regular physical activity, and other supportive practices, you can enhance the medication’s effectiveness while minimizing potential side effects.

Below are practical tips to help you get the most out of your weight loss journey with Contrave.

1. Follow a Reduced-Calorie Diet

To achieve the best results with Contrave, focus on a reduced-calorie diet that emphasizes balanced, nutrient-rich meals. Incorporate lean proteins (e.g., chicken, fish, tofu), lentils, and a variety of colorful fruits and vegetables to ensure you get essential vitamins and minerals.

Avoid sugary snacks, processed foods, and empty-calorie beverages like soda. Use tools like meal planning apps or consult a dietitian to create a meal plan that fits your caloric needs and dietary preferences.

2. Stay Active

Regular physical activity not only aids in weight loss but also improves digestion and overall well-being. Aim for at least 150 minutes of moderate-intensity aerobic exercise per week, such as brisk walking, cycling, or swimming. Incorporate strength training exercises twice a week to build muscle and boost metabolism.

For beginners, start small with daily 10–15-minute walks, gradually increasing intensity and duration as your fitness level improves.

3. Avoid High-Fat Meals

High-fat meals can exacerbate nausea and interfere with Contrave’s absorption, reducing its effectiveness. Limit your intake of fried foods, fatty meats, and creamy sauces. Instead, choose cooking methods like grilling, steaming, or baking, and use healthy fats in moderation, such as olive oil, avocado, or nuts.

When dining out, opt for lower-fat options like grilled proteins or salads with dressing on the side.

4. Good Sleep Hygiene

Adequate rest is critical for weight management and overall health. Poor sleep can disrupt hunger-regulating hormones like ghrelin and leptin, leading to increased cravings and overeating. Aim for 7–9 hours of quality sleep each night by establishing a consistent bedtime routine.

Avoid screens for at least an hour before bed, create a relaxing environment with dim lighting and comfortable bedding, and limit caffeine intake in the afternoon and evening. If you struggle with sleep, consider relaxation techniques like meditation or deep-breathing exercises.

By implementing these strategies, you can enhance the effectiveness of Contrave while supporting a sustainable and healthy weight loss journey.

Conclusion

Contrave constipation is a manageable side effect for many patients. By following dietary recommendations, staying active, and consulting your healthcare provider, you can minimize discomfort while maximizing the medication’s benefits.

If you have concerns about taking Contrave, discuss them with a healthcare professional to ensure it’s the right choice for your weight management journey.

For more information, visit the FDA’s official page on Contrave (opens in a new tab) or consult resources like the Mayo Clinic